She piled on the pounds to play Bridget Jones, popped her bonce in curlers for Chicago and became a nurse called Betty in 2000.
Now Renee Zellweger has hit the dressing up box again for her latest role.
She's been frocked up like a laydee to play children's author Beatrix Potter, in upcoming flick Miss Potter.
Her new look includes a brown hat, heavy layered skirts and what looks like minimal make-up.
To make matters worse, whilst Ren's acting about in dowdy threads, gorgeous Ewan McGregor is among her co-stars in the film.
But we hear he's having to wear a dodgy moustache, so things might be equal after all.
Check out Renee's changing looks throughout the years in the gallery above...
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